Publication list Univ.-Prof. Dr. Gabriele Pradel
  1. Trenholme K, Marek L, Duffy S, Pradel G, Fisher G, Hansen FK, Skinner-Adams TS, Butterworth A, Julius Ngwa C, Moecking J, Goodman CD, McFadden GI, Sumanadasa SD, Fairlie DP, Avery VM, Kurz T, Andrews KT (2014) Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules. Antimicrob Agents Chemother, in press.
  2. Wirth CC, Glushakova S, Scheuermayer M, Repnik U, Garg S, Schaack D, Kachman MM, Weißbach T, Zimmerberg J, Dandekar T, Griffiths G, Chitnis CE, Singh S, Fischer R, Pradel G (2014) Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes. Cell Microbiol 16(5):709-33
  3. Feller T, Thom P, Koch N, Spiegel H, Addai-Mensah O, Fischer R, Reimann A, Pradel G, Fendel R, Schillberg S, Scheuermayer M, Schinkel H (2013) Plant-based production of recombinant Plasmodium surface protein pf38 and evaluation of its potential as a vaccine candidate. PLoS One 8(11):e79920.
  4. Lödige M, Lewis MD, Paulsen ES, Esch HL, Pradel G, Lehmann L, Brun R, Bringmann G, Mueller AK (2013) A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages. Int J Med Microbiol 303(8):539-47
  5. Tschan S, Brouwer AJ, Werkhoven PR, Jonker AM, Wagner L, Knittel S, Aminake MN, Pradel G, Joanny F, Liskamp RM, Mordmüller B (2013) Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors. Antimicrob Agents Chemother 57(8):3576-84
  6. Ngwa CJ, Scheuermayer M, Mair GR, Kern S, Brügl T, Wirth CC, Aminake MN, Wiesner J, Fischer R, Vilcinskas A, Pradel G (2013) Changes in the transcriptome of the malaria parasite Plasmodium falciparum during the initial phase of transmission from the human to the mosquito. BMC Genomics 14:256
  7. Ngwa CJ, Glöckner V, Abdelmohsen UR, Scheuermayer M, Fischer R, Hentschel U, Pradel G (2013) 16S rRNA gene-based identification of Elizabethkingia meningoseptica (Flavobacteriales: Flavobacteriaceae) as a dominant midgut bacterium of the Asian malaria vector Anopheles stephensi (Dipteria: Culicidae) with antimicrobial activities. J Med Entomol 50(2):404-14
  8. Deligianni E, Morgan RN, Bertuccini L, Wirth CC, Silmon de Monerri NC, Spanos L, Blackman MJ, Louis C, Pradel G, Siden-Kiamos I (2013) A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes. Cell Microbiol 15(8):1438-55.
  9. Simon N, Lasonder E, Scheuermayer M, Kuehn A, Tews S, Fischer R, Zipfel PF, Skerka C, Pradel G (2013) Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Cell Host Microbe 13(1):29-41
  10. Wirth CC, Pradel G (2012) Molecular mechanisms of host cell egress by malaria parasites. Int J Med Microbiol 302(4-5):172-8
  11. Aminake MN, Mahajan A, Kumar V, Hans R, Wiesner L, Taylor D, de Kock C, Grobler A, Smith PJ, Kirschner M, Rethwilm A, Pradel G, Chibale K (2012) Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy. Bioorg Med Chem 20(17):5277-89
  12. Aminake MN, Arndt, HD, Pradel G (2012) The proteasome of malaria parasites: a multi-stage drug target for chemotherapeutic intervention? Int J Parasitol Drugs Drug Resistance 2:1-10
  13. Röhrich CR, Ngwa CJ, Wiesner J, Schmidtberg H, Degenkolb T, Kollewe C, Fischer R, Pradel G, Vilcinskas A (2012) Harmonine, a defence compound from the harlequin ladybird, inhibits mycobacterial growth and demonstrates multi-stage antimalarial activity. Biol Lett 8(2):308-11
  14. Tischer M, Pradel G, Ohlsen K, Holzgrabe U (2012) Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions? ChemMedChem 7(1):22-31
  15. Solyakov L, Halbert J, Alam MM, Semblat JP, Dorin-Semblat D, Reininger L, Bottrill AR, Mistry S, Abdi A, Fennell C, Holland Z, Demarta C, Bouza Y, Sicard A, Nivez MP, Eschenlauer S, Lama T, Thomas DC, Sharma P, Agarwal S, Kern S, Pradel G, Graciotti M, Tobin AB, Doerig C (2011) Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum. Nat Commun 2:565
  16. Humeida H, Pradel G, Stich A, Krawinkel MB (2011) The effect of glucose and insulin on in vitro proliferation of Plasmodium falciparum. J. Diabetol 3:6.
  17. Sologub L, Kuehn A, Kern S, Przyborski J, Schillig R, Pradel G (2011) Malaria proteases mediate inside-out egress of gametocytes from red blood cells following parasite transmission to the mosquito. Cell Microbiol 13(6):897-912
  18. Agarwal S, Kern S, Halbert J, Przyborski JM, Baumeister S, Dandekar T, Doerig C, Pradel G (2011) Two nucleus-localized CDK-like kinases with crucial roles for malaria parasite erythrocytic replication are involved in phosphorylation of splicing factor. J Cell Biochem 112(5):1295-310
  19. Coppi A, Natarajan R, Pradel G, Bennett BL, James ER, Roggero MA, Corradin G, Persson C, Tewari R, Sinnis P (2011) The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host. J Exp Med 208(2):341-56
  20. Aminake MN, Schoof S, Sologub L, Leubner M, Kirschner M, Arndt HD, Pradel G (2011) Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast. Antimicrob Agents Chemother 55 (4):1338-48
  21. Rupp I, Sologub L, Williamson KC, Scheuermayer M, Reininger L, Doerig C, Eksi S, Kombila DU, Frank M, Pradel G (2011) Malaria parasites form filamentous cell-to-cell connections during reproduction in the mosquito midgut. Cell Res 21(4):683-96
  22. Kuehn A, Simon N, Pradel G (2010) Family members stick together: multi-protein complexes of malaria parasites. Med Microbiol Immunol 199 (3):209-26
  23. Tischer M, Sologub L, Pradel G, Holzgrabe U (2010) The bisnaphthalimides as new active lead compounds against Plasmodium falciparum. Bioorg Med Chem 18(9):2998-3003
  24. Schoof S, Pradel G, Aminake MN, Ellinger B, Baumann S, Potowski M, Najajreh Y, Kirschner M, Arndt HD (2011) Antiplasmodial thiostrepton derivatives: proteasome inhibitors with a dual mode of action. Angew Chem Int Ed Engl 49(19):3317-21
  25. Pradel G, Schlitzer M (2010) Antibiotics in malaria therapy and their effect on the parasite apicoplast. Curr Mol Med 10(3):335-49
  26. Purcell LA, Leitao R, Ono T, Yanow SK, Pradel G, Spithill TW, Rodriguez A (2010) A putative kinase-related protein (PKRP) from Plasmodium berghei mediates infection in the midgut and salivary glands of the mosquito. Int J Parasitol 40(8):979-88
  27. Kuehn A, Pradel G (2010) The coming-out of malaria gametocytes. J Biomed Biotechnol 2010:976827
  28. Mitra BN, Pradel G, Frevert U, Eichinger D (2010) Compounds of the upper gastrointestinal tract induce rapid and efficient excystation of Entamoeba invadens. Int J Parasitol 40(6):751-60
  29. Nowotny B, Schneider T, Pradel G, Schirmeister T, Rethwilm A, Kirschner M (2010) Inducible APOBEC3G-Vif double stable cell line as a high-throughput screening platform to identify antiviral compounds. Antimicrob Agents Chemother 54(1):78-87
  30. Doerig C, Baker D, Billker O, Blackman MJ, Chitnis C, Dhar Kumar S, Heussler V, Holder AA, Kocken C, Krishna S, Langsley G, Lasonder E, Menard R, Meissner M, Pradel G, Ranford-Cartwright L, Sharma A, Sharma P, Tardieux T, Tatu U, Alano P (2009) Signalling in malaria parasites. The MALSIG consortium. Parasite 16(3):169-82
  31. Simon N, Scholz SM, Moreira CK, Templeton TJ, Kuehn A, Dude MA, Pradel G (2009) Sexual stage adhesion proteins form multi-protein complexes in the malaria parasite Plasmodium falciparum. J Biol Chem 284(21):14537-46
  32. Dude MA, Kaeppler U, Herb M, Schiller M, Schulz F, Vedder B, Heppner S, Pradel G, Gut J, Rosenthal PJ, Schirmeister T, Leippe M, Gelhaus C (2008) Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid. Molecules 14(1):19-35
  33. Yanow SK, Purcell LA, Pradel G, Sato A, Rodriguez A, Lee M, Spithill TW (2008) Potent antimalarial and transmission-blocking activities of centanamycin, a novel DNA-binding agent. J Infect Dis 197(4):527-34
  34. Rupp I, Bosse R, Schirmeister T, Pradel G (2008) Effect of protease inhibitors on exflagellation in Plasmodium falciparum. Mol Biochem Parasitol 158(2):208-12
  35. Ettari R, Nizi E, Di Francesco ME, Dude MA, Pradel G, Vicík R, Schirmeister T, Micale N, Grasso S, Zappalà M (2008) Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors. J Med Chem 51(4):988-96
  36. Barthel D, Schlitzer M, Pradel G (2008) Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum. Antimicrob Agents Chemother 52(2):774-7
  37. Scholz SM, Simon N, Lavazec C, Dude MA, Templeton TJ, Pradel G (2008) PfCCp proteins of Plasmodium falciparum: gametocyte-specific expression and role in complement-mediated inhibition of exflagellation. Int J Parasitol 38(3-4):327-40
  38. Pradel G (2007) Proteins of the malaria parasite sexual stages: expression, function and potential for transmission blocking strategies. Parasitology 134(Pt.14):1911-29
  39. Pradel G, Wagner C, Mejia C, Templeton TJ (2006) Plasmodium falciparum: Co-dependent expression and co-localization of the PfCCp multi-adhesion domain proteins. Exp Parasitol 112(4):263-8
  40. Korochkina S, Barreau C, Pradel G, Jeffery E, Li J, Natarajan R, Shabanowitz J, Hunt D, Frevert U, Vernick KD (2006) A mosquito-specific protein family includes candidate receptors for malaria sporozoite invasion of salivary glands. Cell Microbiol 8(1):163-75
  41. Pradel G, Hayton K, Aravind L, Iyer LM, Abrahamsen MS, Bonawitz A, Mejia C, Templeton TJ (2004) A multidomain adhesion protein family expressed in Plasmodium falciparum is essential for transmission to the mosquito. J Exp Med 199(11):1533-44
  42. Pradel G, Garapaty S, Frevert U (2004) Kupffer and stellate cell proteoglycans mediate malaria sporozoite targeting to the liver. Comp Hepatol 3 (Suppl1):S47
  43. Pradel G, Garapaty S, Frevert U (2002) Proteoglycans mediate malaria sporozoite targeting to the liver. Mol Microbiol 45(3):637-51
  44. Pradel G, Frevert U (2001) Malaria sporozoites actively enter and pass through rat Kupffer cells prior to hepatocyte invasion. Hepatology 33(5):1154-65
  45. Mota MM, Pradel G, Vanderberg JP, Hafalla JC, Frevert U, Nussenzweig RS, Nussenzweig V, Rodríguez A (2001) Migration of Plasmodium sporozoites through cells before infection. Science 291(5501):141-4
  46. Pradel G, Schmidt R, Schachner M (2000) Involvement of L1.1 in memory consolidation after active avoidance conditioning in zebrafish. J Neurobiol 43(4):389-403
  47. Pradel G, Schachner M, Schmidt R (1999) Inhibition of memory consolidation by antibodies against cell adhesion molecules after active avoidance conditioning in zebrafish. J Neurobiol 39(2):197-206
  48. Hügel FU, Pradel G, Frevert U (1996) Release of malaria circumsporozoite protein into the host cell cytoplasm and interaction with ribosomes. Mol Biochem Parasitol 81(2):151-70
  49. Robson KJ, Frevert U, Reckmann I, Cowan G, Beier J, Scragg IG, Takehara K, Bishop DH, Pradel G, Sinden R, et al (1995) Thrombospondin-related adhesive protein (TRAP) of Plasmodium falciparum: expression during sporozoite ontogeny and binding to human hepatocytes. EMBO J 14(16):3883-94