Cell-free expression of multifunctional plant virus nanoparticles

Electron microscopy image of Tobacco mosaic virus Copyright: © RWTH Aachen Bio7

Functionalized plant virus nanoparticles have gained growing interest and impact in diverse biomedical applications, because they are biocompatible and biodegradable and can be easily functionalized by modifying their repetitive coat protein (CP) structures.

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Synthetic plant virology

Three Luminescent Plants Copyright: © RWTH Aachen Bio7

The working group „Synthetic plant virology“ deals with modified plant viruses, which allow to produce desired proteins quickly and in large quantities. The virus moves independently through the plant, replicating and producing both its own proteins and foreign proteins.

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DFG project PlantVirusBone

microscopic section of plantvirusbone Copyright: © RWTH Aachen Bio7

In collaboration with Professor Dr.-Ing. Horst Fischer, RWTH Aachen University Hospital, Department of Dental Materials and Biomaterials Research Aachen

Biomineralizing three-dimensional bioprinted hydrogels for bone tissue replacement using dedicated osteogenic peptides in high local concentrations presented on biotechnologically modified plant virus nanoparticles (PlantVirusBone)

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Plant biotechnology

microscopic section of a cell wall Copyright: © RWTH Aachen Bio7

Recombinant therapeutic proteins and protein-based vaccines are playing an important role in modern medicine and healthcare. Plants and plant cell cultures are beginning to establish themselves in the highly competitive field of biotechnological production systems for recombinant proteins.

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Light controllable systems on plant virus surfaces

Light controllable proteins offer the possibility to specifically control the building of protein pairs and thereby influence sundry cellular and molecular processes. These light controllable systems gain increasing interest in the field of biomedicine and biomaterial production. Light represents the effective stimulus for the binding of the protein pairs as it can be applied with a high degree of spatial and temporal control and low costs. Furthermore, the light excitation can target a precise location in the body and the light spectrum is wide.

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